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Clemmer Group

Jonathan M. Dilger

Educational Background

• Ph.D.: Biological Chemistry; Indiana University, Bloomington, IN. In progress...
• M.B.A.: Management and Marketing of Emerging Technologies; Miller College of Business, Ball State University, Muncie, IN. May 2005.
• B.S.: Biology; Indiana University, Bloomington, IN. May 2003

Areas of Research

• Enhancement of predictive detection techniques of molecules of interest using ion mobility spectrometry (IMS) instrumentation.
• Improvement of small molecule selectivity of detection via fragmentation techniques upon mobility selection and collisional activation, as applied to for chemical warfare agent mobility simulants to decrease false positive alarms.
• Examination of the influence of metals on the gas-phase conformations of peptide ions and development of predictive techniques using mobility-derived intrinsic size parameters.
• Development of a mobility database of metal-peptide ions to elucidate general interactions of peptide residues with metal cations in the absence of a solvent environment.

Selected Publications

2. Dilger, J.M., Valentine, S.J., Glover, M.S., Ewing, M.A., Clemmer, D.E. A Database of Alkali Metal-Containing Peptide Cross Sections: Influence of Metals on Size Parameters for Specific Amino Acids. Accepted Int. J. Mass Spectrom. March, 2012
1. Valentine, S.J., Ewing, M.A., Dilger, J.M., Glover,M.S., Geromanos, S., Hughes, C., Clemmer, D. E. Using Ion Mobility Data to Improve Peptide Identification: Cross Section Databases and Intrinsic Amino Acid Size Parameters. J. Proteome Res., 2011, 10 (5), 2318–2329.

Presented Posters

5. M. S. Glover, J. M. Dilger, D. E. Clemmer, "Examining the Influence of Divalent Metals on Peptide Ion Conformations by IMS-IMS and CID" 60th ASMS Conference, Vancouver, BC, Canada, May 2012.
4. J. M. Dilger, M. S. Glover, S. J. Valentine, D. E. Clemmer, "A Mobility Database of Cationized Peptide Ions: Explorations in Metal-Peptide Binding Effects on Structure", Turkey Run Analytical Conference, Sept. 2011.
3. M. A. Ewing, S. J. Valentine, J. M. Dilger, M. S. Glover, S. Geromanos, C. Hughes, D. E. Clemmer, "The Use of a Cross Section Database and Intrinsic Amino Acid Size Parameters for the Improvement of Peptide Identification", 59th ASMS Conference, Denver, CO, Jun 2011.
2. J. M. Dilger, M. S. Glover, S. J. Valentine, D. E. Clemmer, "A Mobility Database of Cationized Peptide Ions: Explorations in Metal-Peptide Binding Effects on Structure", 59th ASMS Conference, Denver, CO, Jun 2011.
1. J. M. Dilger, R. S. Glaskin, J. T. Shelley, G. M. Hieftje, S. J. Valentine, D. E. Clemmer, "Improving Selectivity and Sensitivity of Anti-Terrorism Detection Equipment with FAPA-IMS-IMS", 58th ASMS Conference, Salt Lake City, UT, May 2010.

Lectures and Presentations

3. "Gas-Phase Prediction Techniques to Algorithmically Enhance Molecular Detection", NSWC Crane Science & Technology Review, Crane, IN, 24 February 2012.
2. "Probing Metal-Peptide Ion Conformations in the Gas Phase Using IMS-MS Techniques", PhD Candidacy Exam, Bloomington, IN, 26 April 2011.
1. "Radiation Safety Guidelines for Vehicle Inspection Cargo Screener (VICS) System Installation", NAVSEA Radiological Affairs Support Program Conference, San Antonio, TX, 27 February 2008.

Contact Information

Jonathan may be contacted with questions concerning his areas of research through email or through the laboratory telephone (812.855.6462).